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Archive for September 19th, 2009

Chikungunya Makes West Nile Look Like Nappy Rash

Posted by feww on September 19, 2009

Chikungunya is coming!

Chikungunya is hyper-endemic in the islands of the Indian Ocean. Travel by air will import the infected mosquitoes and humans —Dr James Diaz

The ink hadn’t quite dried on

Arctic ice cover third-smallest area on record

in which the FEWW Moderators, discussing the dire effects of climate change on human health,  wrote:

‘Warmer [and dirtier] waters increase mosquito reproduction, which in turn increase the incidence of  mosquito-borne infectious diseases.’

When the news of  Chikungunya arrived.

Chikungunya, a mosquito-borne disease, much worse than the West Nile virus, could become the next nightmare epidemic in the US and Europe.

Aedes aegypti mosquito biting human
Stegomyia aegypti (formerly Aedes aegypti) mosquito siting on a human. Photo: USDA.

Who’s Afraid of Chikungunya?

“We’re very worried,” Dr. James Diaz of the Louisiana University Health Sciences Center told a meeting on airlines, airports and disease transmission sponsored by the independent U.S. National Research Council.

“Unlike West Nile virus, where nine out of 10 people are going to be totally asymptomatic, or may have a mild headache or a stiff neck, if you get Chikungunya you’re going to be sick,” he said.

“The disease can be fatal. It’s a serious disease [and] there is no vaccine.” Diaz added.

The virus can be carried by the Asian tiger mosquito, which is abundant in  Asia, Africa, Australia and New Zealand, as well as Europe, the Americas.

Chikungunya has also been reported in the islands of Mauritius, Seychelles and Reunion, in the Indian ocean, which are among prime beach resorts destinations visited by European tourists.

“It is hyper-endemic in the islands of the Indian Ocean,” Diaz told the meeting.

“Travel by air will import the infected mosquitoes and humans. Chikungunya is coming.” Diaz added.”

What’s Chikungunya

Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes.  Chikungunya virus is a member of the genus Alphavirus, in the family Togaviridae. Chikungunya fever is diagnosed based on symptoms, physical findings (e.g., joint swelling), laboratory testing, and the possibility of exposure to infected mosquitoes. There is no specific treatment for chikungunya fever; care is based on symptoms. Chikungunya infection is not usually fatal. Steps to prevent infection with chikungunya virus include use of insect repellent, protective clothing, and staying in areas with screens. Chikungunya virus was first isolated from the blood of a febrile patient in Tanzania in 1953, and has since been cited as the cause of numerous human epidemics in many areas of Africa and Asia and most recently in limited areas of Europe.—CDC

Chikungunya Distribution and Global Map

ChikV_WorldMap

The geographic range of chikungunya virus is mainly in Africa and Asia.  Given the current large chikungunya virus epidemics and the worldwide distribution of Aedes aegypti and Aedes albopictus mosquitoes, there is a risk of importing chikungunya virus into new area through infected travelers. —CDC

Countries where people have become infected with chikungunya virus.
Benin Mayotte
Burundi Myanmar
Cambodia Nigeria
Cameroon Pakistan
Central African Republic Philippines
Comoros Reunion
Congo, DRC Senegal
East Timor Seychelles
Gabon Singapore
Guinea South Africa
India Sri Lanka
Indonesia Sudan
Italy Taiwan
Kenya Tanzania
Laos Thailand
Madagascar Uganda
Malawi Vietnam
Malaysia Zimbabwe
Mauritius
This list does not include countries where only imported cases have been reported.

Chikungunya Fact Sheet (CDC update: March 4, 2008)

Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes. Chikungunya virus was first isolated from the blood of a febrile patient in Tanzania in 1953, and has since been cited as the cause of numerous human epidemics in many areas of Africa and Asia, and most recently in a limited area of Europe.

What causes chikungunya fever?

Chikungunya fever is caused by a virus which belongs to the genus Alphavirus, in the family Togaviridae.

How do humans become infected with chikungunya virus?
Humans become infected with chikungunya virus by the bite of an infected mosquito. Aedes aegypti, a household container breeder and aggressive daytime biter which is attracted to humans, is the primary vector of chikungunya virus to humans. Aedes albopictus has also played a role in human transmission.

What can people do to prevent becoming infected with chikungunya virus?
The best way to prevent chikungunya virus infection is to avoid mosquito bites. There is no vaccine or preventive drug currently available. Prevention tips are similar to those for other viral diseases transmitted by mosquitoes, such as dengue or West Nile:

  • Use insect repellent containing DEET, Picaridin, oil of lemon eucalyptus, or IR3535 on exposed skin. Always follow the directions on the package.
  • Wear long sleeves and pants (ideally treat clothes with permethrin or another repellent).
  • Have secure screens on windows and doors to keep mosquitoes out.
  • Get rid of mosquito sources in your yard by emptying standing water from flower pots, buckets and barrels. Change the water in pet dishes and replace the water in bird baths weekly. Drill holes in tire swings so water drains out. Keep children’s wading pools empty and on their sides when they aren’t being used.
  • Additionally, a person with chikungunya fever should limit their exposure to mosquito bites to avoid further spreading the infection. The person should use repellents when outdoors exposed to mosquito bites or stay indoors in areas with screens or under a mosquito net.

What is the basic chikungunya virus transmission cycle?
Mosquitoes become infected with chikungunya virus when they feed on an infected person. Infected mosquitoes can then spread the virus to other humans when they bite them. Monkeys, and possibly other wild animals, may also serve as reservoirs of the virus. Aedes aegypti, a household container breeder and aggressive daytime biter which is attracted to humans, is the primary vector of chikungunya virus to humans. Aedes albopictus (the Asian tiger mosquito) has also played a role in human transmission is Asia, Africa, and Europe. Various forest-dwelling mosquito species in Africa have been found to be infected with the virus.

What type of illness does chikungunya virus cause?
Chikungunya virus infection can cause a debilitating illness, most often characterized by fever, headache, fatigue, nausea, vomiting, muscle pain, rash, and joint pain. “Silent” chikungunya virus infections (infections without illness) do occur; but how commonly this happens is not yet known. Chikungunya virus infection (whether clinically apparent or silent) is thought to confer life-long immunity. Acute chikungunya fever typically lasts a few days to a couple of weeks, but as with dengue, West Nile fever, o’nyong-nyong fever and other arboviral fevers, some patients have prolonged fatigue lasting several weeks. Additionally, some patients have reported incapacitating joint pain, or arthritis which may last for weeks or months.

What is the incubation period for chikungunya fever?

The incubation period (time from infection to illness) can be 2-12 days, but is usually 3-7 days.

Can pregnant women become infected with chikungunya virus and pass the infection to their child?
Pregnant women can become infected with chikungunya virus during all stages of pregnancy and have symptoms similar to other individuals. Most infections will not result in the virus being transmitted to the fetus. The highest risk for infection of the fetus/child occurs when a woman has virus in her blood (viremic) at the time of delivery. There are also rare reports of first trimester abortions occurring after chikungunya infection. Pregnant women should take precautions to avoid mosquito bites. Products containing DEET can be used in pregnancy without adverse effects.

Can the virus be transmitted to a child by breastfeeding?
Currently, there is no evidence that the virus is transmitted through breast milk

What is the mortality rate of chikungunya fever?
Fatalities related to chikungunya virus are rare and appear to be associated to increased age.

How is chikungunya virus infection treated?

There is no vaccine or specific antiviral treatment currently available for chikungunya fever. Treatment is symptomatic and can include rest, fluids, and medicines to relieve symptoms of fever and aching such as ibuprofen, naproxen, acetaminophen, or paracetamol. Aspirin should be avoided. Infected persons should be protected from further mosquito exposure (staying indoors in areas with screens and/or under a mosquito net) during the first few days of the illness so they can not contribute to the transmission cycle.

Where does chikungunya virus occur?
The geographic range of the virus is primarily in Africa and Asia. For information on current outbreaks, consult CDC’s Travelers’ Health website (http://wwwn.cdc.gov/travel/default.aspx). Given the current large chikungunya virus epidemics and the world wide distribution of Aedes aegypti and Aedes albopictus, there is a risk of importation of chikungunya virus into new areas by infected travelers.

Content source:

Division of Vector Borne Infectious Diseases
National Center for Zoonotic, Vector-Borne, and Enteric Diseases

Related Links:

Posted in Alphavirus, Asian Tiger mosquito, Louisiana University Health Sciences Center, Tanzania, Togaviridae, U.S. National Research Council, West Nile virus | Tagged: , , , , , , , , | Leave a Comment »

Latest Earthquakes Magnitude 5.5 +

Posted by feww on September 19, 2009

Latest Earthquakes Measuring Magnitude 5.5 or Larger since September 18, 2009

The following significant earthquakes occurred within a 12-hour period.

The Bali Earthquake detailed below was reported as a Magnitude  6.0  shock by the  European-Mediterranean Seismological Center. 

GFZ Potsdam – Earthquake Bulletin
Region: South of Bali, Indonesia
Time: 2009-09-18 at 23:06:59.5 UTC
Magnitude: 5.9
Epicenter: 115.42°E 9.47°S
Depth: 77 km
Status: automatic
gfz2009simp location map

The quake was described as “very strong” by a number of people who sopke to the media. People were reportedly jumping from building and running away from their homes in panic after the quake struck. Up to a dozen people have been injured, some hurt jumping from buildings while others were hit by falling debris, according to news reports quoting officials.  No tsunami warning was issued.

An earthquake on the main Indonesian island of Java left more than 50 dead on September 2, 2009.

The 9.3 Mw Sumatra-Andaman earthquake which caused the 2004 Indian Ocean tsunami that killed an estimated quarter of million people in 11 countries, was the second largest earthquake recorded on a seismograph. The earthquake was also characterized by the longest ever duration of faulting lasting about 10 minutes, which made the entire planet to vibrate about 1 cm triggering earthquakes as far north as in Alaska.

FEWW Comments: More Mega-quakes should be expected in this region and other areas in the coming months. FEWW will post a separate [disturbing] forecast later.

Magnitude 5.6 – REVILLA GIGEDO ISLANDS REGION

  • Date-Time:  Friday, September 18, 2009 at 18:46:08 UTC [Friday, September 18, 2009 at 11:46:08 AM at epicenter]
  • Location: 19.239°N, 108.494°W
  • Depth 10 km (6.2 miles)
  • Distances: 265 km (165 miles) ENE of Socorro Island, Mexico
  • Source: USGS NEIC (WDCS-D)

10-degree Map Centered at 20°N,110°W

REVILLA GIGEDO ISLANDS REGION
EQ Location Map. Source of original map: USGS

GFZ Potsdam – Earthquake Bulletin

Region: Halmahera, Indonesia
Time: 2009-09-18 at 18:34:25.6 UTC
Magnitude: 5.7
Epicenter: 127.16°E 1.80°N
Depth: 110 km

Status: manually revised
gfz2009sidp location map

GFZ Potsdam – Earthquake Bulletin

GFZ Potsdam – Earthquake Bulletin
Region: Mindanao, Philippines
Time: 2009-09-18 11:53:50.2 UTC
Magnitude: 5.5
Epicenter: 124.71°E 6.51°N
Depth: 23 km
Status: manually revised

gfz2009shqk location map
GFZ Potsdam Images
© Helmholtz-Zentrum Potsdam Deutsches GeoForschungsZentrum – GFZ

Related Links:

Posted in Alaska quake, Bali quake, Indian Ocean tsunami, Java Quake, Mega-Quakes, REVILLA GIGEDO ISLANDS, Sumatra-Andaman earthquake, tsunami warning | Tagged: , , , , , , , , , | Leave a Comment »

“Flesh Eating Bacteria” Linked to NSAIDs

Posted by feww on September 19, 2009

Global Health Alert  Bulletin # 30 – New Zealand cases of “flesh-eating” disease have surged by 300 percent

Flesh Eating Bug is linked to Nurofen, and similar non-steroidal anti-inflammatory (NSAIDs) medicine including Voltaren

Caution has also been issued on using ibuprofen in chickenpox!

Preoperative view (NF Patient)

NF NZ Med-Js
Areas of blistering and skin necrosis became evident 12 hours after patient was admitted to hospital with lower abdominal pain, swelling of the labia and erythema across the lower suprapubic area. Photo: The New Zealand Medical Journal.

Post debridement defect

NF NZ Med-J 02 sl
Post debridement (removal of infected tissues) photo. Image source: The New Zealand Medical Journal.


What is Necrotizing Fasciitis, NF  [commonly know as flesh-eating disease]

Necrotizing fasciitis (NF), commonly called flesh-eating disease or flesh-eating bacteria, is an infection of the deeper layers of skin and subcutaneous tissues.

  • Type I infection is a polymicrobial infection.
  • Type II infection is  a monomicrobial infection.

Many types of bacteria can cause necrotizing fasciitis

  • Group A streptococcus (Streptococcus pyogenes)
  • Staphylococcus aureus
  • Vibrio vulnificus,
  • Clostridium perfringens
  • Bacteroides fragilis

Historically, Group A streptococcus has been responsible for  most cases of Type II infections. However, since about 1999, another serious form of monomicrobial necrotizing fasciitis,  the methicillin resistant Staphylococcus aureus (MRSA) bacterium has struck with increasing frequency.

What the bugs do!

“Flesh-eating bacteria” [they don’t actually eat flesh]  destroy skin and muscle tissue by releasing toxins (virulence factors), which include streptococcal pyogenic exotoxins.

Causes

  • Surgical procedures
  • IV infusions and IM injections
  • Minor insect bites
  • Superficial wounds
  • Local ischemia and hypoxia especially in patients with diabetes and cancer (and other systemic illnesses)
  • Up to 40 percent of the patients in various series were alcoholics
  • The use of nonsteroidal anti-inflammatory agents (NSAIDs), such as Nurofen, Vultaren and Ibuprofen
  • Complications arising from varicella infections

NF Symptoms

  • Infection begins locally, at a site of trauma.
  • Infection may occur as the result of surgery, minor scratches, or even non-apparent.
  • Signs of inflammation may not be apparent if the bacteria are deep within the tissue, especially in the early stages,
  • Intense pain that may seem excessive given the external appearance of the skin.
  • As the disease progresses, tissue becomes swollen, often within hours.
  • Diarrhea and vomiting.
  • Signs of inflammation such as redness and swollen or hot skin show very quickly, unless infection is deep.
  • Skin color may progress to violet and blisters may form, with subsequent death of the subcutaneous tissues.
  • Fever and appearance of severe illness.
  • The infection will rapidly progress, and will eventually lead to death, unless treated.
  • Mortality rates are as high as 73 percent when left untreated.

Treatment

  • Aggressive surgical debridement (removal of infected tissue), which  is always necessary to keep the disease  from spreading, and is usually the only treatment available.
  • A combination of intravenous antibiotics including penicillin, vancomycin and clindamycin.
  • Hyperbaric oxygen treatment, when available, as  adjunctive therapy,
  • Negative pressure wound therapy (NPWT, also known as vacuum assisted closure).
  • Amputation of the affected organ(s) .
  • Skin grafting to cover open wounds

MRSA

MRSA [Methicillin-resistant Staphylococcus aureus] was discovered in the United Kingdom in 1961, but it is now a global concern. MRSA (also known as CA-MRSA, community-acquired MRSA, and HA-MRSA, hospital-acquired MRSA) is a variation of a common bacterium, which has evolved as a “superbug” with the ability to resist treatment with antibiotics, including methicillin and penicillin.

According to Centers for Disease Control and Prevention (CDC), MRSA is responsible for 94,000 serious infections and nearly 19,000 deaths each year in the United States. [In comparison, the AIDS virus killed about 12,500 Americans  in 2005. ]

Causes

MRSA is a strain of Staphylococcus aureus (S. aureus) bacteria. S. aureus is a common type of bacteria that normally live on the skin and sometimes in the nasal passages of healthy people. MRSA refers to S. aureus strains that do not respond to some of the antibiotics used to treat staph infections.

The bacteria can cause infection when they enter the body through a cut, sore, catheter, or breathing tube. The infection can be minor and local (for example, a pimple), or more serious (involving the heart, lung, blood, or bone).

Serious staph infections are more common in people with weak immune systems. This includes patients in hospitals and long-term care facilities and those receiving kidney dialysis.

MRSA infections are grouped into two types:

  • Healthcare-associated MRSA (HA-MRSA) infections occur in people who are or have recently been in a hospital or other health-care facility. Those who have been hospitalized or had surgery within the past year are at increased risk. MRSA bacteria are responsible for a large percentage of hospital-acquired staph infections.
  • Community-associated MRSA (CA-MRSA) infections occur in otherwise healthy people who have not recently been in the hospital. The infections have occurred among athletes who share equipment or personal items (such as towels or razors) and children in daycare facilities. Members of the military and those who get tattoos are also at risk. The number of CA-MRSA cases is increasing.

MRSA Symptoms

Staph skin infections cause a red, swollen, and painful area on the skin. Other symptoms may include:

  • Drainage of pus or other fluids from the site
  • Fever
  • Skin abscess
  • Warmth around the infected area

Symptoms of a more serious staph infection may include:

  • Chest pain
  • Chills
  • Cough
  • Fatigue
  • Fever
  • General ill feeling (malaise)
  • Headache
  • Muscle aches
  • Rash
  • Shortness of breath

Related Links:

The above information was sourced from the CDC, MedLine Plus and other sources.

Posted in amputation, Group A Streptococcus, methicillin resistant, S. aureus, surgical debridement | Tagged: , , , , , , , , , , | 6 Comments »