Marburg Hemorrhagic Fever Breaks Out in SW Uganda
Posted by feww on October 20, 2012
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Outbreak of Deadly Marburg Disease in SW Uganda Kills 5, Leaves 6 Hospitalized
An outbreak of deadly Marburg disease has left at least 5 people dead and 6 others hospitalized in SW Uganda, reports said.
The latest death occurred in Bukora Kitumba in Kabale district, said a report.
The following information is provided by CDC:
Marburg Hemorrhagic Fever
Marburg hemorrhagic fever (Marburg HF) is a rare, severe type of hemorrhagic fever which affects both humans and non-human primates. Caused by a genetically unique zoonotic (that is, animal-borne) RNA virus of the filovirus family, its recognition led to the creation of this virus family. The five subtypes of Ebola virus are the only other known members of the filovirus family.
Marburg virus virion. A colorized negative stained transmission electron micrograph (TEM), captured by F.A. Murphy in 1968, depicts a Marburg virus virion, which had been grown in an environment of tissue culture cells. Marburg hemorrhagic fever is a rare, severe type of hemorrhagic fever which affects both humans and non-human primates. Caused by a genetically unique zoonotic (that is, animal-borne) RNA virus of the filovirus family, its recognition led to the creation of this virus family. The four species of Ebola virus are the only other known members of the filovirus family. See PHIL 7219 for a black and white version of this image.
After an incubation period of 5-10 days, the onset of the disease is sudden and is marked by fever, chills, headache, and myalgia. Around the fifth day after the onset of symptoms, a maculopapular rash, most prominent on the trunk (chest, back, stomach), may occur. Nausea, vomiting, chest pain, a sore throat, abdominal pain, and diarrhea then may appear. Symptoms become increasingly severe and may include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, and multi-organ dysfunction. Because many of the signs and symptoms of Marburg hemorrhagic fever are similar to those of other infectious diseases, such as malaria or typhoid fever, diagnosis of the disease can be difficult, especially if only a single case is involved. [CDC/ Frederick Murphy.]
Marburg virus was first recognized in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). A total of 31 people became ill; they included laboratory workers as well as several medical personnel and family members who had cared for them. There were 7 deaths among the reported cases. The first people infected had been exposed to African green monkeys or their tissues. In Marburg, the monkeys had been imported for research and to prepare polio vaccine. In addition to the 31 cases, an additional primary case was retrospectively serologically diagnosed.
Other Details of MHF
- The case-fatality rate for Marburg hemorrhagic fever is between 23-90%, CDC reported.
- An outbreak of Marburg in the Democratic Republic of Congo in 2000 claimed at least 128 lives (83% fatality rate).
- Another outbreak in Angola killed at least 227 prople in 2005 (90% fatality rate).
Viral Hemorrhagic Fevers (VHFs)
Viral hemorrhagic fevers (VHFs) are a group of diseases caused by ribonucleic acid (RNA) viruses from four distinct families. These diseases include Ebola Hemorrhagic Fever, Marburg Hemorrhagic Fever, Lassa fever, Hantavirus Pulmonary Syndrome, and Yellow Fever. Symptoms vary with the disease, but often include fever, fatigue, and muscle aches. There may be bleeding, although death from blood loss is rare. Severe cases can include shock and coma. Although some types of VHFs are relatively mild illnesses, many of them can cause severe, life-threatening disease with high fatality rates.
Along with smallpox, anthrax, plague, botulism, and tularemia, hemorrhagic fever viruses are among the six agents identified by the Centers for Disease Control and Prevention (CDC) as the most likely to be used as biological weapons. Many VHFs can cause severe, life-threatening disease with high fatality rates. Source: U.S. Gov.
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This entry was posted on October 20, 2012 at 12:20 pm and is filed under Global Disaster watch, global disasters, global disasters 2012, global health catastrophe. Tagged: Bukora Kitumba, deadly virus outbreak, Ebola virus, filovirus family, Marburg Disease, Marburg Hemorrhagic Fever, Marburg virus, Marburg virus virion, outbreak of deadly disease, Uganda, Viral hemorrhagic fever, Viral Hemorrhagic Fevers. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.